Identification of Substituted Pyrimido[5,4-b]indoles as Selective Toll-Like Receptor 4 Ligands

[Image: see text] A cell-based high-throughput screen to identify small molecular weight stimulators of the innate immune system revealed substituted pyrimido[5,4-b]indoles as potent NFκB activators. The most potent hit compound selectively stimulated Toll-like receptor 4 (TLR4) in human and mouse c...

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Detalhes bibliográficos
Main Authors: Chan, Michael, Hayashi, Tomoko, Mathewson, Richard D., Nour, Afshin, Hayashi, Yuki, Yao, Shiyin, Tawatao, Rommel I., Crain, Brian, Tsigelny, Igor F., Kouznetsova, Valentina L., Messer, Karen, Pu, Minya, Corr, Maripat, Carson, Dennis A., Cottam, Howard B.
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2013
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3722616/
https://ncbi.nlm.nih.gov/pubmed/23656327
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm301694x
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