Synthetic Toll-Like Receptor 4 (TLR4) and TLR7 Ligands Work Additively via MyD88 To Induce Protective Antiviral Immunity in Mice

We previously demonstrated that the combination of synthetic small-molecule Toll-like receptor 4 (TLR4) and TLR7 ligands is a potent adjuvant for recombinant influenza virus hemagglutinin, inducing rapid and sustained immunity that is protective against influenza viruses in homologous, heterologous,...

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Detalhes bibliográficos
Publicado no:J Virol
Main Authors: Goff, Peter H., Hayashi, Tomoko, He, Wenqian, Yao, Shiyin, Cottam, Howard B., Tan, Gene S., Crain, Brian, Krammer, Florian, Messer, Karen, Pu, Minya, Carson, Dennis A., Palese, Peter, Corr, Maripat
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2017
Assuntos:
Vaccines and Antiviral Agents
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5599744/
https://ncbi.nlm.nih.gov/pubmed/28724768
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01050-17
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