TLR4/MyD88/PI3K interactions regulate TLR4 signaling

TLRs activate immune responses by sensing microbial structures such as bacterial LPS, viral RNA, and endogenous “danger” molecules released by damaged host cells. MyD88 is an adapter protein that mediates signal transduction for most TLRs and leads to activation of NF-κB and MAPKs and production of...

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Hlavní autoři: Laird, Michelle H. W., Rhee, Sang Hoon, Perkins, Darren J., Medvedev, Andrei E., Piao, Wenji, Fenton, Matthew J., Vogel, Stefanie N.
Médium: Artigo
Jazyk:Inglês
Vydáno: The Society for Leukocyte Biology 2009
Témata:
Receptors, Signal Transduction, and Genes
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2698589/
https://ncbi.nlm.nih.gov/pubmed/19289601
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1189/jlb.1208763
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