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Endotoxin tolerance dysregulates MyD88- and Toll/IL-1R domain-containing adapter inducing IFN-β-dependent pathways and increases expression of negative regulators of TLR signaling

Endotoxin tolerance reprograms cell responses to LPS by repressing expression of proinflammatory cytokines, while not inhibiting production of anti-inflammatory cytokines and antimicrobial effectors. Molecular mechanisms of induction and maintenance of endotoxin tolerance are incompletely understood...

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Main Authors: Piao, Wenji, Song, Chang, Chen, Haiyan, Quevedo Diaz, Marco A., Wahl, Larry M., Fitzgerald, Katherine A., Li, Liwu, Medvedev, Andrei E.
格式: Artigo
語言:Inglês
出版: The Society for Leukocyte Biology 2009
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2796624/
https://ncbi.nlm.nih.gov/pubmed/19656901
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1189/jlb.0309189
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