TLR4/MyD88/PI3K interactions regulate TLR4 signaling

TLRs activate immune responses by sensing microbial structures such as bacterial LPS, viral RNA, and endogenous “danger” molecules released by damaged host cells. MyD88 is an adapter protein that mediates signal transduction for most TLRs and leads to activation of NF-κB and MAPKs and production of...

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Bibliographische Detailangaben
Hauptverfasser: Laird, Michelle H. W., Rhee, Sang Hoon, Perkins, Darren J., Medvedev, Andrei E., Piao, Wenji, Fenton, Matthew J., Vogel, Stefanie N.
Format: Artigo
Sprache:Inglês
Veröffentlicht: The Society for Leukocyte Biology 2009
Schlagworte:
Receptors, Signal Transduction, and Genes
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2698589/
https://ncbi.nlm.nih.gov/pubmed/19289601
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1189/jlb.1208763
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