Synthetic Toll-Like Receptor 4 (TLR4) and TLR7 Ligands as Influenza Virus Vaccine Adjuvants Induce Rapid, Sustained, and Broadly Protective Responses

Current vaccines against influenza virus infection rely on the induction of neutralizing antibodies targeting the globular head of the viral hemagglutinin (HA). Protection against seasonal antigenic drift or sporadic pandemic outbreaks requires further vaccine development to induce cross-protective...

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Detalhes bibliográficos
Publicado no:J Virol
Main Authors: Goff, Peter H., Hayashi, Tomoko, Martínez-Gil, Luis, Corr, Maripat, Crain, Brian, Yao, Shiyin, Cottam, Howard B., Chan, Michael, Ramos, Irene, Eggink, Dirk, Heshmati, Mitra, Krammer, Florian, Messer, Karen, Pu, Minya, Fernandez-Sesma, Ana, Palese, Peter, Carson, Dennis A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2015
Assuntos:
Vaccines and Antiviral Agents
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4337541/
https://ncbi.nlm.nih.gov/pubmed/25568203
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.03337-14
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