Synthetic Toll-Like Receptor 4 (TLR4) and TLR7 Ligands as Influenza Virus Vaccine Adjuvants Induce Rapid, Sustained, and Broadly Protective Responses

Current vaccines against influenza virus infection rely on the induction of neutralizing antibodies targeting the globular head of the viral hemagglutinin (HA). Protection against seasonal antigenic drift or sporadic pandemic outbreaks requires further vaccine development to induce cross-protective...

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Vydáno v:J Virol
Hlavní autoři: Goff, Peter H., Hayashi, Tomoko, Martínez-Gil, Luis, Corr, Maripat, Crain, Brian, Yao, Shiyin, Cottam, Howard B., Chan, Michael, Ramos, Irene, Eggink, Dirk, Heshmati, Mitra, Krammer, Florian, Messer, Karen, Pu, Minya, Fernandez-Sesma, Ana, Palese, Peter, Carson, Dennis A.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2015
Témata:
Vaccines and Antiviral Agents
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4337541/
https://ncbi.nlm.nih.gov/pubmed/25568203
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.03337-14
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