Structure–Activity Relationship Studies of Pyrimido[5,4-b]indoles as Selective Toll-Like Receptor 4 Ligands

Previous high throughput screening studies led to the discovery of two novel, nonlipid-like chemotypes as Toll-like receptor 4 (TLR4) agonists. One of these chemotypes, the pyrimido[5,4-b]indoles, was explored for structure–activity relationship trends relative to production of TLR4 dependent cytoki...

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Publicado en:J Med Chem
Main Authors: Chan, Michael, Kakitsubata, Yuhei, Hayashi, Tomoko, Ahmadi, Alast, Yao, Shiyin, Shukla, Nikunj M., Oyama, Shin-ya, Baba, Akihito, Nguyen, Brandon, Corr, Maripat, Suda, Yasuo, Carson, Dennis A., Cottam, Howard B., Wakao, Masahiro
Formato: Artigo
Idioma:Inglês
Publicado: 2017
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5940354/
https://ncbi.nlm.nih.gov/pubmed/29049886
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.7b00797
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