Increased levels of urinary phenylacetylglycine associated with mitochondrial toxicity in a model of drug-induced phospholipidosis

BACKGROUND: Phospholipidosis (PLD) is a lysosomal storage disorder induced by a class of cationic amphiphilic drugs. However, drug-induced PLD is reversible. Evidence of PLD from animal studies with some compounds has led to discontinuation of development. Regulatory authorities are likely to reques...

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Detalhes bibliográficos
Main Authors: Doessegger, Lucette, Schmitt, Georg, Lenz, Barbara, Fischer, Holger, Schlotterbeck, Götz, Atzpodien, Elke-Astrid, Senn, Hans, Suter, Laura, Csato, Miklos, Evers, Stefan, Singer, Thomas
Formato: Artigo
Idioma:Inglês
Publicado em: SAGE Publications 2013
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Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4110864/
https://ncbi.nlm.nih.gov/pubmed/25083254
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/2042098613479393
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