Repeated Administration of a Mutant Cocaine Esterase: Effects on Plasma Cocaine Levels, Cocaine-Induced Cardiovascular Activity, and Immune Responses in Rhesus Monkeys

Previous studies have demonstrated the capacity of a long-acting mutant form of a naturally occurring bacterial double mutant cocaine esterase (DM CocE) to antagonize the reinforcing, discriminative, convulsant, and lethal effects of cocaine in rodents and reverse the increases in mean arterial pres...

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Main Authors: Collins, Gregory T., Brim, Remy L., Noon, Kathleen R., Narasimhan, Diwahar, Lukacs, Nicholas W., Sunahara, Roger K., Woods, James H., Ko, Mei-Chuan
Formato: Artigo
Idioma:Inglês
Publicado: The American Society for Pharmacology and Experimental Therapeutics 2012
Assuntos:
Drug Discovery and Translational Medicine
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3383034/
https://ncbi.nlm.nih.gov/pubmed/22518021
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.112.194639
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