Amelioration of the Cardiovascular Effects of Cocaine in Rhesus Monkeys by a Long-Acting Mutant Form of Cocaine Esterase

A long-acting mutant form of a naturally occurring bacterial cocaine esterase (T172R/G173Q CocE; double mutant CocE (DM CocE)) has previously been shown to antagonize the reinforcing, convulsant, and lethal effects of cocaine in rodents. However, the effectiveness and therapeutic characteristics of...

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Detalhes bibliográficos
Main Authors: Collins, Gregory T, Carey, Kathy A, Narasimhan, Diwahar, Nichols, Joseph, Berlin, Aaron A, Lukacs, Nicholas W, Sunahara, Roger K, Woods, James H, Ko, Mei-Chuan
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2011
Assuntos:
Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3076304/
https://ncbi.nlm.nih.gov/pubmed/21289605
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/npp.2010.242
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