Synthesis and biological evaluation of 6-substituted indolizinoquinolinediones as catalytic DNA topoisomerase I inhibitors

Por Yu, Le-Mao, Zhang, Xiao-Ru, Li, Xiao-Bing, Yang, Yuan, Wei, Hong-Yu, He, Xi-Xin, Gu, Lian-Quan, Huang, Zhi-Shu, Pommier, Yves, An, Lin-Kun
Publicado no Eur J Med Chem (2015)

Probing the Structural Requirements of Non-electrophilic Naphthalene-Based Nrf2 Activators

Por Jain, Atul D., Potteti, Haranatha, Richardson, Benjamin G., Kingsley, Laura, Luciano, Julia P., Ryuzoji, Aya F., Lee, Hyun, Krunic, Aleksej, Mesecar, Andrew D., Reddy, Sekhar P., Moore, Terry W.
Publicado no Eur J Med Chem (2015)

Identification of novel cyclic lipopeptides from a positional scanning combinatorial library with enhanced antibacterial and antibiofilm activities

Por Bionda, Nina, Fleeman, Renee M., de la Fuente-Núñez, César, Rodriguez, Maria C., Reffuveille, Fany, Shaw, Lindsey N., Pastar, Irena, Davis, Stephen C., Hancock, Robert E. W., Cudic, Predrag
Publicado no Eur J Med Chem (2015)

A structural insight into the P1-S1 binding mode of diaminoethylphosphonic and phosphinic acids, selective inhibitors of alanine aminopeptidases

Por Węglarz-Tomczak, Ewelina, Berlicki, Łukasz, Pawełczak, Małgorzata, Nocek, Bogusław, Joachimiak, Andrzej, Mucha, Artur
Publicado no Eur J Med Chem (2016)

Antitrypanosomal activity of 5-nitro-2-aminothiazole-based compounds

Por Papadopoulou, Maria V., Bloomer, William D., Rosenzweig, Howard S., Wilkinson, Shane R., Szular, Joanna, Kaiser, Marcel
Publicado no Eur J Med Chem (2016)

Synthesis, molecular modeling and biological evaluation of novel tadalafil analogues as phosphodiesterase 5 and colon tumor cell growth inhibitors, new stereochemical perspective

Por Abadi, Ashraf H., Gary, Bernard D., Tinsley, Heather N., Piazza, Gary A., Abdel-Halim, Mohammad
Publicado no Eur J Med Chem (2010)

Synthesis and in Vitro Evaluation of New Analogues as Inhibitors for Phosphodiesterase 10A

Por Zhang, Zhanbin, Lu, Xiaoxia, Xu, Jinbin, Rothfuss, Justin, Mach, Robert H., Tu, Zhude
Publicado em 2011

One-pot synthesis and biological evaluation of 2-pyrrolidinyl-4-amino-5-(3′,4′,5′-trimethoxybenzoyl)thiazole: A unique, highly active antimicrotubule agent

Por Romagnoli, Romeo, Baraldi, Pier Giovanni, Cara, Carlota Lopez, Salvador, Maria Kimatrai, Bortolozzi, Roberta, Basso, Giuseppe, Viola, Giampietro, Balzarini, Jan, Brancale, Andrea, Fu, Xian-Hua, Li, Jun, Zhang, Su-Zhan, Hamel, Ernest
Publicado em 2011

Dendrimer-based Multivalent Methotrexates as Dual Acting Nanoconjugates for Cancer Cell Targeting

Por Li, Ming-Hsin, Choi, Seok Ki, Thomas, Thommey P., Desai, Ankur, Lee, Kyung-Hoon, Kotlyar, Alina, Banaszak Holl, Mark M., Baker, James R.
Publicado em 2011

Novel Triacsin C Analogs as Potential Antivirals against Rotavirus Infections

Por Kim, Yunjeong, George, David, Prior, Allan M., Prasain, Keshar, Hao, Shuanghong, Le, Duy D., Hua, Duy H., Chang, Kyeong-Ok
Publicado em 2012

Synthesis and biological activity of substituted 2,4-diaminopyrimidines that inhibit Bacillus anthracis

Por Nammalwar, Baskar, Bunce, Richard A., Berlin, K. Darrell, Bourne, Christina R., Bourne, Philip C., Barrow, Esther W., Barrow, William W.
Publicado em 2012

Potent Direct Inhibitors of Factor Xa Based on the Tetrahydroisoquinoline Scaffold

Por Al-Horani, Rami A., Mehta, Akul Y., Desai, Umesh R.
Publicado em 2012

Fragment-based drug design and identification of HJC0123, a novel orally bioavailable STAT3 inhibitor for cancer therapy

Por Chen, Haijun, Yang, Zhengduo, Ding, Chunyong, Chu, Lili, Zhang, Yusong, Terry, Kristin, Liu, Huiling, Shen, Qiang, Zhou, Jia
Publicado em 2013

Toward synthesis of third-generation spin-labeled podophyllotoxin derivatives using isocyanide multicomponent reactions

Por Kou, Liang, Wang, Mei-Juan, Wang, Li-Ting, Zhao, Xiao-Bo, Nan, Xiang, Yang, Liu, Liu, Ying-Qian, Morris-Natschke, Susan L., Lee, Kuo-Hsiung
Publicado em 2014

Selective cytotoxicity, inhibition of cell cycle progression, and induction of apoptosis in human breast cancer cells by sesquiterpenoids from Inula lineariifolia Turcz.

Por Qin, Jiang-Jiang, Jin, Hui-Zi, Huang, Ying, Zhang, Shou-De, Shan, Lei, Voruganti, Sukesh, Nag, Subhasree, Wang, Wei, Zhang, Wei-Dong, Zhang, Ruiwen
Publicado em 2013

Design, synthesis and biological evaluation of arylcinnamide hybrid derivatives as novel anticancer agents

Por Romagnoli, Romeo, Baraldi, Pier Giovanni, Salvador, Maria Kimatrai, Chayah, Mariem, Camacho, M. Encarnacion, Prencipe, Filippo, Hamel, Ernest, Consolaro, Francesca, Basso, Giuseppe, Viola, Giampietro
Publicado em 2014

Michael Acceptor Approach to the Design of New Salvinorin A-based High Affinity Ligands for the Kappa-Opioid Receptor

Por Polepally, Prabhakar R., Huben, Krzysztof, Vardy, Eyal, Setola, Vincent, Mosier, Philip D., Roth, Bryan L., Zjawiony, Jordan K.
Publicado em 2014

Synthesis and evaluation of imidazole-4,5- and pyrazine-2,3-dicarboxamides targeting dengue and yellow fever virus()

Por Saudi, Milind, Zmurko, Joanna, Kaptein, Suzanne, Rozenski, Jef, Neyts, Johan, Van Aerschot, Arthur
Publicado no Eur J Med Chem (2014)

Scaffold hopping approach on the route to selective tankyrase inhibitors

Por Liscio, Paride, Carotti, Andrea, Asciutti, Stefania, Ferri, Martina, Pires, Maira M., Valloscuro, Sara, Ziff, Jacob, Clark, Neil R., Macchiarulo, Antonio, Aaronson, Stuart A., Pellicciari, Roberto, Camaioni, Emidio
Publicado no Eur J Med Chem (2014)

Design and Structure Activity Relationship of Tumor-Homing Histone Deacetylase Inhibitors Conjugated to Folic and Pteroic Acids

Por Sodji, Quaovi H., Kornacki, James R., McDonald, John, Mrksich, Milan, Oyelere, Adegboyega K.
Publicado no Eur J Med Chem (2015)