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Scaffold hopping approach on the route to selective tankyrase inhibitors
A virtual screening procedure was applied to identify new tankyrase inhibitors. Through pharmacophore screening of a compounds collection from the SPECS database, the methoxy[l]benzothieno[2,3-c]quinolin-6(5H)-one scaffold was identified as nicotinamide mimetic able to inhibit tankyrase activity at...
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| Опубликовано в: : | Eur J Med Chem |
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| Главные авторы: | , , , , , , , , , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2014
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4415586/ https://ncbi.nlm.nih.gov/pubmed/25299683 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejmech.2014.10.007 |
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