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Poly(ADP-ribose) Catabolism Triggers AMP-dependent Mitochondrial Energy Failure
Upon massive DNA damage, hyperactivation of the nuclear enzyme poly(ADP-ribose) polymerase (PARP)-1 causes severe depletion of intracellular NAD and ATP pools as well as mitochondrial dysfunction. Thus far, the molecular mechanisms contributing to PARP-1-dependent impairment of mitochondrial functio...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2719406/ https://ncbi.nlm.nih.gov/pubmed/19411252 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.002931 |
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