Poly(ADP-ribose) Catabolism Triggers AMP-dependent Mitochondrial Energy Failure

Upon massive DNA damage, hyperactivation of the nuclear enzyme poly(ADP-ribose) polymerase (PARP)-1 causes severe depletion of intracellular NAD and ATP pools as well as mitochondrial dysfunction. Thus far, the molecular mechanisms contributing to PARP-1-dependent impairment of mitochondrial functio...

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Bibliografiset tiedot
Päätekijät: Formentini, Laura, Macchiarulo, Antonio, Cipriani, Giulia, Camaioni, Emidio, Rapizzi, Elena, Pellicciari, Roberto, Moroni, Flavio, Chiarugi, Alberto
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: American Society for Biochemistry and Molecular Biology 2009
Aiheet:
Metabolism and Bioenergetics
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC2719406/
https://ncbi.nlm.nih.gov/pubmed/19411252
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.002931
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