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Herpes Simplex Virus 1 Infection Activates Poly(ADP-Ribose) Polymerase and Triggers the Degradation of Poly(ADP-Ribose) Glycohydrolase

Herpes simplex virus 1 infection triggers multiple changes in the metabolism of host cells, including a dramatic decrease in the levels of NAD(+). In addition to its role as a cofactor in reduction-oxidation reactions, NAD(+) is required for certain posttranslational modifications. Members of the po...

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Autors principals: Grady, Sarah L., Hwang, Jesse, Vastag, Livia, Rabinowitz, Joshua D., Shenk, Thomas
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2012
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3421676/
https://ncbi.nlm.nih.gov/pubmed/22623791
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00495-12
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