Design, Synthesis, Crystallographic Studies, and Preliminary Biological Appraisal of New Substituted Triazolo[4,3-b]pyridazin-8-amine Derivatives as Tankyrase Inhibitors

Searching for selective tankyrases (TNKSs) inhibitors, a new small series of 6,8-disubstituted triazolo[4,3-b]piridazines has been synthesized and characterized biologically. Structure-based optimization of the starting hit compound NNL (3) prompted us to the discovery of 4-(2-(6-methyl-[1,2,4]triaz...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:J Med Chem
Main Authors: Liscio, Paride, Carotti, Andrea, Asciutti, Stefania, Karlberg, Tobias, Bellocchi, Daniele, Llacuna, Laura, Macchiarulo, Antonio, Aaronson, Stuart A, Schüler, Herwig, Pellicciari, Roberto, Camaioni, Emidio
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4406096/
https://ncbi.nlm.nih.gov/pubmed/24527792
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm401356t
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados