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Michael Acceptor Approach to the Design of New Salvinorin A-based High Affinity Ligands for the Kappa-Opioid Receptor

The neoclerodane diterpenoid salvinorin A is a major secondary metabolite isolated from the psychoactive plant Salvia divinorum. Salvinorin A has been shown to have high affinity and selectivity for the κ-opioid receptor (KOR). To study the ligand–receptor interactions that occur between salvinorin...

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Detalhes bibliográficos
Main Authors: Polepally, Prabhakar R., Huben, Krzysztof, Vardy, Eyal, Setola, Vincent, Mosier, Philip D., Roth, Bryan L., Zjawiony, Jordan K.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4162805/
https://ncbi.nlm.nih.gov/pubmed/25193297
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejmech.2014.07.077
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