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Studies Toward the Pharmacophore of Salvinorin A, a Potent Kappa Opioid Receptor Agonist
Salvinorin A (1), from the sage Salvia divinorum, is a potent and selective kappa opioid receptor (KOR) agonist. We screened other salvinorins and derivatives for binding affinity and functional activity at opioid receptors. Our results suggest that the methyl ester and furan ring are required for a...
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| Autors principals: | , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2005
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2777653/ https://ncbi.nlm.nih.gov/pubmed/15658846 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm049438q |
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