Modification of the furan ring of salvinorin A: identification of a selective partial agonist at the kappa opioid receptor

In an effort to find novel agents which selectively target the kappa opioid receptor (KOPR), we modified the furan ring of the highly potent and selective KOPR agonist salvinorin A. Introduction of small substituents at C-16 was well tolerated. 12-epi-Salvinorin A, synthesized in four steps from sal...

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Bibliographic Details
Main Authors: Béguin, Cécile, Duncan, Katharine K., Munro, Thomas A., Ho, Douglas M., Xu, Wei, Liu-Chen, Lee-Yuan, Carlezon, William A., Cohen, Bruce M.
Format: Artigo
Language:Inglês
Published: 2008
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2680211/
https://ncbi.nlm.nih.gov/pubmed/19147366
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2008.12.012
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