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Modification of the furan ring of salvinorin A: identification of a selective partial agonist at the kappa opioid receptor
In an effort to find novel agents which selectively target the kappa opioid receptor (KOPR), we modified the furan ring of the highly potent and selective KOPR agonist salvinorin A. Introduction of small substituents at C-16 was well tolerated. 12-epi-Salvinorin A, synthesized in four steps from sal...
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| Main Authors: | , , , , , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2008
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2680211/ https://ncbi.nlm.nih.gov/pubmed/19147366 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2008.12.012 |
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