Standard Protecting Groups Create Potent and Selective κ Opioids: Salvinorin B Alkoxymethyl Ethers

Protection of salvinorin B as standard alkoxyalkyl ethers yielded highly potent κ opioid receptor agonists. Ethoxymethyl ether 6 is among the most potent and selective κ agonists reported to date. Fluoroethoxymethyl ether 11 is the first potent, selective fluorinated κ ligand, with potential use in...

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Main Authors: Munro, Thomas A., Duncan, Katharine K., Xu, Wei, Wang, Yulin, Liu-Chen, Lee-Yuan, Carlezon, William A., Cohen, Bruce M., Béguin., Cécile
Format: Artigo
Jezik:Inglês
Izdano: 2007
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2568987/
https://ncbi.nlm.nih.gov/pubmed/17981041
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2007.10.067
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