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2-Methoxymethyl-Salvinorin B Is a Potent κ Opioid Receptor Agonist with Longer Lasting Action in Vivo Than Salvinorin A

Salvinorin (Sal) A is a naturally occurring, selective κ opioid receptor (KOPR) agonist with a short duration of action in vivo. Pharmacological properties of a C(2) derivative, 2-methoxy-methyl (MOM)-Sal B, were characterized. MOM-Sal B bound to KOPR with high selectivity and displayed ~3-fold high...

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Bibliografiske detaljer
Main Authors: Wang, Yulin, Chen, Yong, Xu, Wei, Lee, David Y.W., Ma, Zhongze, Rawls, Scott M., Cowan, Alan, Liu-Chen, Lee-Yuan
Format: Artigo
Sprog:Inglês
Udgivet: 2007
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2519046/
https://ncbi.nlm.nih.gov/pubmed/18089845
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.107.132142
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