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CoMFA Analyses of C-2 Position Salvinorin A Analogs at the Kappa-Opioid Receptor Provides Insights into Epimer Selectivity

The highly potent and kappa-opioid receptor (KOR)-selective hallucinogen salvinorin A and selected analogs have been analyzed using the 3D quantitative structure-affinity relationship technique Comparative Molecular Field Analysis (CoMFA) in an effort to derive a statistically significant and predic...

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Détails bibliographiques
Auteurs principaux: McGovern, Donna L., Mosier, Philip D., Roth, Bryan L., Westkaemper, Richard B.
Format: Artigo
Langue:Inglês
Publié: 2010
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2859180/
https://ncbi.nlm.nih.gov/pubmed/20083418
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmgm.2009.12.008
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