Cathepsin B Degrades Amyloid-β in Mice Expressing Wild-type Human Amyloid Precursor Protein

por Wang, Chao, Sun, Binggui, Zhou, Yungui, Grubb, Anders, Gan, Li
Publicado 2012

Imbalance between GABAergic and Glutamatergic Transmission Impairs Adult Neurogenesis in an Animal Model of Alzheimer’s Disease

por Sun, Binggui, Halabisky, Brian, Zhou, Yungui, Palop, Jorge J., Yu, Guiqiu, Mucke, Lennart, Gan, Li
Publicado 2009

CX3CR1 Protein Signaling Modulates Microglial Activation and Protects against Plaque-independent Cognitive Deficits in a Mouse Model of Alzheimer Disease

por Cho, Seo-Hyun, Sun, Binggui, Zhou, Yungui, Kauppinen, Tiina M., Halabisky, Brian, Wes, Paul, Ransohoff, Richard M., Gan, Li
Publicado 2011

Cystatin C–Cathepsin B Axis Regulates Amyloid Beta Levels and Associated Neuronal Deficits in an Animal Model of Alzheimer’s Disease

por Sun, Binggui, Zhou, Yungui, Halabisky, Brian, Lo, Iris, Cho, Seo-Hyun, Mueller-Steiner, Sarah, Wang, Xin, Grubb, Anders, Gan, Li
Publicado 2008

A MAC2-positive progenitor-like microglial population is resistant to CSF1R inhibition in adult mouse brain

por Zhan, Lihong, Fan, Li, Kodama, Lay, Sohn, Peter Dongmin, Wong, Man Ying, Mousa, Gergey Alzaem, Zhou, Yungui, Li, Yaqiao, Gan, Li
Publicado en eLife (2020)

Selective targeting of microglia by quantum dots

por Minami, S Sakura, Sun, Binggui, Popat, Ketul, Kauppinen, Tiina, Pleiss, Mike, Zhou, Yungui, Ward, Michael E, Floreancig, Paul, Mucke, Lennart, Desai, Tejal, Gan, Li
Publicado 2012

Acetylated tau destabilizes the cytoskeleton in the axon initial segment and is mislocalized to the somatodendritic compartment

por Sohn, Peter Dongmin, Tracy, Tara E., Son, Hye-In, Zhou, Yungui, Leite, Renata E. P., Miller, Bruce L., Seeley, William W., Grinberg, Lea T., Gan, Li
Publicado en Mol Neurodegener (2016)

Discovery of small molecules that normalize the transcriptome and enhance cysteine cathepsin activity in progranulin-deficient microglia

por Telpoukhovskaia, Maria A., Liu, Kai, Sayed, Faten A., Etchegaray, Jon Iker, Xie, Min, Zhan, Lihong, Li, Yaqiao, Zhou, Yungui, Le, David, Bahr, Ben A., Bogyo, Matthew, Ding, Sheng, Gan, Li
Publicado en Sci Rep (2020)

Progranulin Protects against Amyloid β Deposition and Toxicity in Alzheimer’s Disease Mouse Models

por Minami, S. Sakura, Min, Sang-Won, Krabbe, Grietje, Wang, Chao, Zhou, Yungui, Asgarov, Rustam, Li, Yaqiao, Martens, Lauren H., Elia, Lisa P., Ward, Michael E., Mucke, Lennart, Farese, Robert V., Gan, Li
Publicado 2014

Acetylation of Tau Inhibits Its Degradation and Contributes to Tauopathy

por Min, Sang-Won, Cho, Seo-Hyun, Zhou, Yungui, Schroeder, Sebastian, Haroutunian, Vahram, Seeley, William W., Huang, Eric J., Shen, Yong, Masliah, Eliezer, Mukherjee, Chandrani, Meyers, David, Cole, Philip A., Ott, Melanie, Gan, Li
Publicado 2010

SIRT1 Deficiency in Microglia Contributes to Cognitive Decline in Aging and Neurodegeneration via Epigenetic Regulation of IL-1β

por Cho, Seo-Hyun, Chen, Jason A., Sayed, Faten, Ward, Michael E., Gao, Fuying, Nguyen, Thi A., Krabbe, Grietje, Sohn, Peter Dongmin, Lo, Iris, Minami, Sakura, Devidze, Nino, Zhou, Yungui, Coppola, Giovanni, Gan, Li
Publicado en J Neurosci (2015)

Phospholipase A(2) reduction ameliorates cognitive deficits in a mouse model of Alzheimer's disease

por Sanchez-Mejia, Rene O., Newman, John W., Toh, Sandy, Yu, Gui-Qiu, Zhou, Yungui, Halabisky, Brian, Cissé, Moustapha, Scearce-Levie, Kimberly, Cheng, Irene H., Gan, Li, Palop, Jorge J., Bonventre, Joseph V., Mucke, Lennart
Publicado 2008

Differential effects of partial and complete loss of TREM2 on microglial injury response and tauopathy

por Sayed, Faten A., Telpoukhovskaia, Maria, Kodama, Lay, Li, Yaqiao, Zhou, Yungui, Le, David, Hauduc, Axel, Ludwig, Connor, Gao, Fuying, Clelland, Claire, Zhan, Lihong, Cooper, Yonatan A., Davalos, Dimitrios, Akassoglou, Katerina, Coppola, Giovanni, Gan, Li
Publicado en Proc Natl Acad Sci U S A (2018)

Proximal recolonization by self-renewing microglia re-establishes microglial homeostasis in the adult mouse brain

por Zhan, Lihong, Krabbe, Grietje, Du, Fei, Jones, Ian, Reichert, Meredith C., Telpoukhovskaia, Maria, Kodama, Lay, Wang, Chao, Cho, Seo-hyun, Sayed, Faten, Li, Yaqiao, Le, David, Zhou, Yungui, Shen, Yin, West, Brian, Gan, Li
Publicado en PLoS Biol (2019)

Acetylated Tau Obstructs KIBRA-Mediated Signaling in Synaptic Plasticity and Promotes Tauopathy-Related Memory Loss

por Tracy, Tara E., Sohn, Peter Dongmin, Minami, S. Sakura, Wang, Chao, Min, Sang-Won, Li, Yaqiao, Zhou, Yungui, Le, David, Lo, Iris, Ponnusamy, Ravikumar, Cong, Xin, Schilling, Birgit, Ellerby, Lisa M., Huganir, Richard L., Gan, Li
Publicado en Neuron (2016)

Microglial microRNAs mediate sex-specific responses to tau pathology

por Kodama, Lay, Guzman, Elmer, Etchegaray, Jon I., Li, Yaqiao, Sayed, Faten A., Zhou, Lu, Zhou, Yungui, Zhan, Lihong, Le, David, Udeochu, Joe C., Clelland, Claire D., Cheng, Zuolin, Yu, Guoqiang, Li, Qingyun, Kosik, Kenneth S., Gan, Li
Publicado en Nat Neurosci (2019)

Critical Role of Acetylation in Tau-Mediated Neurodegeneration and Cognitive Deficits

por Min, Sang-Won, Chen, Xu, Tracy, Tara E, Li, Yaqiao, Zhou, Yungui, Wang, Chao, Shirakawa, Kotaro, Minami, S. Sakura, Defensor, Erwin, Mok, Sue Ann, Sohn, Peter Dongmin, Schilling, Birgit, Cong, Xin, Ellerby, Lisa, Gibson, Bradford W., Johnson, Jeffrey, Krogan, Nevan, Shamloo, Mehrdad, Gestwicki, Jason, Masliah, Eliezer, Verdin, Eric, Gan, Li
Publicado en Nat Med (2015)

An 8-week, open-label, dose-finding study of nimodipine for the treatment of progranulin insufficiency from GRN gene mutations

por Sha, Sharon J., Miller, Zachary A., Min, Sang-won, Zhou, Yungui, Brown, Jesse, Mitic, Laura L., Karydas, Anna, Koestler, Mary, Tsai, Richard, Corbetta-Rastelli, Chiara, Lin, Sophie, Hare, Emma, Fields, Scott, Fleischmann, Kirsten E., Powers, Ryan, Fitch, Ryan, Martens, Lauren Herl, Shamloo, Mehrdad, Fagan, Anne M., Farese, Robert V., Pearlman, Rodney, Seeley, William, Miller, Bruce L., Gan, Li, Boxer, Adam L.
Publicado en Alzheimers Dement (N Y) (2017)