Cystatin C–Cathepsin B Axis Regulates Amyloid Beta Levels and Associated Neuronal Deficits in an Animal Model of Alzheimer’s Disease

Impaired degradation of amyloid beta (Aβ) peptides could lead to Aβ accumulation, an early trigger of Alzheimer’s disease (AD). Regulation of Aβ-degrading enzymes remains largely unknown. Cystatin C (CysC, CST3) is an endogenous inhibitor of cysteine proteases, including cathepsin B (CatB), a recent...

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Detalhes bibliográficos
Main Authors: Sun, Binggui, Zhou, Yungui, Halabisky, Brian, Lo, Iris, Cho, Seo-Hyun, Mueller-Steiner, Sarah, Wang, Xin, Grubb, Anders, Gan, Li
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2755563/
https://ncbi.nlm.nih.gov/pubmed/18957217
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuron.2008.10.001
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