Discovery of small molecules that normalize the transcriptome and enhance cysteine cathepsin activity in progranulin-deficient microglia

Patients with frontotemporal dementia (FTD) resulting from granulin (GRN) haploinsufficiency have reduced levels of progranulin and exhibit dysregulation in inflammatory and lysosomal networks. Microglia produce high levels of progranulin, and reduction of progranulin in microglia alone is sufficien...

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Vydáno v:Sci Rep
Hlavní autoři: Telpoukhovskaia, Maria A., Liu, Kai, Sayed, Faten A., Etchegaray, Jon Iker, Xie, Min, Zhan, Lihong, Li, Yaqiao, Zhou, Yungui, Le, David, Bahr, Ben A., Bogyo, Matthew, Ding, Sheng, Gan, Li
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2020
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7426857/
https://ncbi.nlm.nih.gov/pubmed/32792571
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-70534-9
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