Microglial microRNAs mediate sex-specific responses to tau pathology

Sex is a key modifier of neurological disease outcomes. Microglia are implicated in neurological diseases and modulated by miRNAs, but it is unknown whether microglial miRNAs have sex-specific influences on disease. We show that microglial miRNA expression differs in males and females and that loss...

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Pubblicato in:Nat Neurosci
Autori principali: Kodama, Lay, Guzman, Elmer, Etchegaray, Jon I., Li, Yaqiao, Sayed, Faten A., Zhou, Lu, Zhou, Yungui, Zhan, Lihong, Le, David, Udeochu, Joe C., Clelland, Claire D., Cheng, Zuolin, Yu, Guoqiang, Li, Qingyun, Kosik, Kenneth S., Gan, Li
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2019
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7394069/
https://ncbi.nlm.nih.gov/pubmed/31873194
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41593-019-0560-7
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