Differential effects of partial and complete loss of TREM2 on microglial injury response and tauopathy

Alzheimer’s disease (AD), the most common form of dementia, is characterized by the abnormal accumulation of amyloid plaques and hyperphosphorylated tau aggregates, as well as microgliosis. Hemizygous missense variants in Triggering Receptor Expressed on Myeloid Cells 2 (TREM2) are associated with e...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Sayed, Faten A., Telpoukhovskaia, Maria, Kodama, Lay, Li, Yaqiao, Zhou, Yungui, Le, David, Hauduc, Axel, Ludwig, Connor, Gao, Fuying, Clelland, Claire, Zhan, Lihong, Cooper, Yonatan A., Davalos, Dimitrios, Akassoglou, Katerina, Coppola, Giovanni, Gan, Li
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2018
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6176614/
https://ncbi.nlm.nih.gov/pubmed/30232263
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1811411115
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