Discovery of small molecules that normalize the transcriptome and enhance cysteine cathepsin activity in progranulin-deficient microglia

Patients with frontotemporal dementia (FTD) resulting from granulin (GRN) haploinsufficiency have reduced levels of progranulin and exhibit dysregulation in inflammatory and lysosomal networks. Microglia produce high levels of progranulin, and reduction of progranulin in microglia alone is sufficien...

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Detalhes bibliográficos
Publicado no:Sci Rep
Principais autores: Telpoukhovskaia, Maria A., Liu, Kai, Sayed, Faten A., Etchegaray, Jon Iker, Xie, Min, Zhan, Lihong, Li, Yaqiao, Zhou, Yungui, Le, David, Bahr, Ben A., Bogyo, Matthew, Ding, Sheng, Gan, Li
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7426857/
https://ncbi.nlm.nih.gov/pubmed/32792571
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-70534-9
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