Critical Role of Acetylation in Tau-Mediated Neurodegeneration and Cognitive Deficits

Tauopathies, including frontotemporal dementia (FTD) and Alzheimer’s disease (AD), are neurodegenerative diseases in which tau fibrils accumulate. Recent evidence supports soluble tau species as the major toxic species. How soluble tau accumulates and how it causes neurodegeneration remains unclear....

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Bibliografske podrobnosti
izdano v:Nat Med
Main Authors: Min, Sang-Won, Chen, Xu, Tracy, Tara E, Li, Yaqiao, Zhou, Yungui, Wang, Chao, Shirakawa, Kotaro, Minami, S. Sakura, Defensor, Erwin, Mok, Sue Ann, Sohn, Peter Dongmin, Schilling, Birgit, Cong, Xin, Ellerby, Lisa, Gibson, Bradford W., Johnson, Jeffrey, Krogan, Nevan, Shamloo, Mehrdad, Gestwicki, Jason, Masliah, Eliezer, Verdin, Eric, Gan, Li
Format: Artigo
Jezik:Inglês
Izdano: 2015
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4598295/
https://ncbi.nlm.nih.gov/pubmed/26390242
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.3951
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