SIRT1 Deacetylates Tau and Reduces Pathogenic Tau Spread in a Mouse Model of Tauopathy

Hyperacetylation of tau has been implicated in neurodegeneration and cognitive decline in tauopathy brains. The nicotinamide adenosine dinucleotide-dependent class-III protein deacetylase SIRT1 is one of the major enzymes involved in removal of acetyl groups from tau in vitro. However, whether SIRT1...

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Detalhes bibliográficos
Publicado no:J Neurosci
Principais autores: Min, Sang-Won, Sohn, Peter Dongmin, Li, Yaqiao, Devidze, Nino, Johnson, Jeffrey R., Krogan, Nevan J., Masliah, Eliezer, Mok, Sue-Ann, Gestwicki, Jason E., Gan, Li
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2018
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Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5895994/
https://ncbi.nlm.nih.gov/pubmed/29540553
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.2369-17.2018
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