Progranulin Protects against Amyloid β Deposition and Toxicity in Alzheimer’s Disease Mouse Models

Haploinsufficiency of progranulin (PGRN) gene (GRN) causes familial frontotemporal lobar degeneration (FTLD), and modulates an innate immune response in humans and mouse models. GRN polymorphism may be linked to late-onset Alzheimer’s disease (AD). However, PRGN’s role in AD pathogenesis is unknown....

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Autori principali: Minami, S. Sakura, Min, Sang-Won, Krabbe, Grietje, Wang, Chao, Zhou, Yungui, Asgarov, Rustam, Li, Yaqiao, Martens, Lauren H., Elia, Lisa P., Ward, Michael E., Mucke, Lennart, Farese, Robert V., Gan, Li
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2014
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4196723/
https://ncbi.nlm.nih.gov/pubmed/25261995
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.3672
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