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Progranulin Protects against Amyloid β Deposition and Toxicity in Alzheimer’s Disease Mouse Models
Haploinsufficiency of progranulin (PGRN) gene (GRN) causes familial frontotemporal lobar degeneration (FTLD), and modulates an innate immune response in humans and mouse models. GRN polymorphism may be linked to late-onset Alzheimer’s disease (AD). However, PRGN’s role in AD pathogenesis is unknown....
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Main Authors: | , , , , , , , , , , , , |
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Formato: | Artigo |
Idioma: | Inglês |
Publicado em: |
2014
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Assuntos: | |
Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4196723/ https://ncbi.nlm.nih.gov/pubmed/25261995 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.3672 |
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