Progranulin haploinsufficiency reduces amyloid beta deposition in Alzheimer’s disease model mice

Granulin (Grn) mutations were identified in familial frontotemporal lobar degeneration (FTLD) patients with TAR DNA-binding protein of 43 kd (TDP-43) pathology. Grn transcript haploinsufficiency is proposed as a disease mechanism that leads to the loss of functional progranulin (PGRN) protein. Thus,...

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Detalhes bibliográficos
Publicado no:Exp Anim
Main Authors: Hosokawa, Masato, Tanaka, Yoshinori, Arai, Tetsuaki, Kondo, Hiromi, Akiyama, Haruhiko, Hasegawa, Masato
Formato: Artigo
Idioma:Inglês
Publicado em: Japanese Association for Laboratory Animal Science 2017
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5814315/
https://ncbi.nlm.nih.gov/pubmed/28845019
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1538/expanim.17-0060
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