Molecular Mechanisms in the Pathogenesis of Alzheimer’s disease and Tauopathies-Prion-Like Seeded Aggregation and Phosphorylation

Por Hasegawa, Masato
Publicado no Biomolecules (2016)

The Tauopathies : Toward an Experimental Animal Model

Por Goedert, Michel, Hasegawa, Masato
Publicado em 1999

A Cellular Model To Monitor Proteasome Dysfunction by α-Synuclein†

Por Nonaka, Takashi, Hasegawa, Masato
Publicado em 2009

In vitro recapitulation of aberrant protein inclusions in neurodegenerative diseases: New cellular models of neurodegenerative diseases

Por Nonaka, Takashi, Hasegawa, Masato
Publicado em 2011

Profilin 1 mutants form aggregates that induce accumulation of prion-like TDP-43

Por Tanaka, Yoshinori, Hasegawa, Masato
Publicado no Prion (2016)

α-Synuclein: Experimental Pathology

Por Hasegawa, Masato, Nonaka, Takashi, Masuda-Suzukake, Masami
Publicado no Cold Spring Harb Perspect Med (2016)

Seeded Aggregation and Toxicity of α-Synuclein and Tau: CELLULAR MODELS OF NEURODEGENERATIVE DISEASES

Por Nonaka, Takashi, Watanabe, Sayuri T., Iwatsubo, Takeshi, Hasegawa, Masato
Publicado em 2010

Templated Aggregation of TAR DNA-binding Protein of 43 kDa (TDP-43) by Seeding with TDP-43 Peptide Fibrils

Por Shimonaka, Shotaro, Nonaka, Takashi, Suzuki, Genjiro, Hisanaga, Shin-ichi, Hasegawa, Masato
Publicado no J Biol Chem (2016)

α-Synuclein in filamentous inclusions of Lewy bodies from Parkinson’s disease and dementia with Lewy bodies

Por Spillantini, Maria Grazia, Crowther, R. Anthony, Jakes, Ross, Hasegawa, Masato, Goedert, Michel
Publicado em 1998

α-Synuclein Fibrils Exhibit Gain of Toxic Function, Promoting Tau Aggregation and Inhibiting Microtubule Assembly

Por Oikawa, Takayuki, Nonaka, Takashi, Terada, Makoto, Tamaoka, Akira, Hisanaga, Shin-ichi, Hasegawa, Masato
Publicado no J Biol Chem (2016)

Conversion of Wild-type α-Synuclein into Mutant-type Fibrils and Its Propagation in the Presence of A30P Mutant

Por Yonetani, Motokuni, Nonaka, Takashi, Masuda, Masami, Inukai, Yuki, Oikawa, Takayuki, Hisanaga, Shin-ichi, Hasegawa, Masato
Publicado em 2009

Methylene Blue Reduced Abnormal Tau Accumulation in P301L Tau Transgenic Mice

Por Hosokawa, Masato, Arai, Tetsuaki, Masuda-Suzukake, Masami, Nonaka, Takashi, Yamashita, Makiko, Akiyama, Haruhiko, Hasegawa, Masato
Publicado em 2012

Pathological alpha-synuclein propagates through neural networks

Por Masuda-Suzukake, Masami, Nonaka, Takashi, Hosokawa, Masato, Kubo, Maki, Shimozawa, Aki, Akiyama, Haruhiko, Hasegawa, Masato
Publicado em 2014

Extracellular association of APP and tau fibrils induces intracellular aggregate formation of tau

Por Takahashi, Muneaki, Miyata, Haruka, Kametani, Fuyuki, Nonaka, Takashi, Akiyama, Haruhiko, Hisanaga, Shin-ichi, Hasegawa, Masato
Publicado no Acta Neuropathol (2015)

The Effect of Fragmented Pathogenic α-Synuclein Seeds on Prion-like Propagation

Por Tarutani, Airi, Suzuki, Genjiro, Shimozawa, Aki, Nonaka, Takashi, Akiyama, Haruhiko, Hisanaga, Shin-ichi, Hasegawa, Masato
Publicado no J Biol Chem (2016)

3R and 4R tau isoforms in paired helical filaments in Alzheimer’s disease

Por Hasegawa, Masato, Watanabe, Sayuri, Kondo, Hiromi, Akiyama, Haruhiko, Mann, David M. A., Saito, Yuko, Murayama, Shigeo
Publicado em 2013

Mass spectrometric analysis of accumulated TDP-43 in amyotrophic lateral sclerosis brains

Por Kametani, Fuyuki, Obi, Tomokazu, Shishido, Takeo, Akatsu, Hiroyasu, Murayama, Shigeo, Saito, Yuko, Yoshida, Mari, Hasegawa, Masato
Publicado no Sci Rep (2016)

Prion-like spreading of pathological α-synuclein in brain

Por Masuda-Suzukake, Masami, Nonaka, Takashi, Hosokawa, Masato, Oikawa, Takayuki, Arai, Tetsuaki, Akiyama, Haruhiko, Mann, David M. A., Hasegawa, Masato
Publicado em 2013

Quantitative and combinatory determination of in situ phosphorylation of tau and its FTDP-17 mutants

Por Kimura, Taeko, Hosokawa, Tomohisa, Taoka, Masato, Tsutsumi, Koji, Ando, Kanae, Ishiguro, Koichi, Hosokawa, Masato, Hasegawa, Masato, Hisanaga, Shin-ichi
Publicado no Sci Rep (2016)

Structure of tau exon 10 splicing regulatory element RNA and destabilization by mutations of frontotemporal dementia and parkinsonism linked to chromosome 17

Por Varani, Luca, Hasegawa, Masato, Spillantini, Maria Grazia, Smith, Michael J., Murrell, Jill R., Ghetti, Bernardino, Klug, Aaron, Goedert, Michel, Varani, Gabriele
Publicado em 1999