Conversion of Wild-type α-Synuclein into Mutant-type Fibrils and Its Propagation in the Presence of A30P Mutant

Fibrillization or conformational change of α-synuclein is central in the pathogenesis of α-synucleinopathies, such as Parkinson disease. We found that the A30P mutant accelerates nucleation-dependent fibrillization of wild type (WT) α-synuclein. Electron microscopy observation and ultracentrifugatio...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: Yonetani, Motokuni, Nonaka, Takashi, Masuda, Masami, Inukai, Yuki, Oikawa, Takayuki, Hisanaga, Shin-ichi, Hasegawa, Masato
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2009
Schlagworte:
Protein Structure and Folding
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2658087/
https://ncbi.nlm.nih.gov/pubmed/19164293
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M807482200
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!

Ähnliche Einträge