Conversion of Wild-type α-Synuclein into Mutant-type Fibrils and Its Propagation in the Presence of A30P Mutant

Fibrillization or conformational change of α-synuclein is central in the pathogenesis of α-synucleinopathies, such as Parkinson disease. We found that the A30P mutant accelerates nucleation-dependent fibrillization of wild type (WT) α-synuclein. Electron microscopy observation and ultracentrifugatio...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Yonetani, Motokuni, Nonaka, Takashi, Masuda, Masami, Inukai, Yuki, Oikawa, Takayuki, Hisanaga, Shin-ichi, Hasegawa, Masato
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2009
Assuntos:
Protein Structure and Folding
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2658087/
https://ncbi.nlm.nih.gov/pubmed/19164293
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M807482200
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados