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Profilin 1 mutants form aggregates that induce accumulation of prion-like TDP-43
Mutations in the profilin 1 (PFN1) gene have been identified as a cause of familial amyotrophic lateral sclerosis (ALS), and neuropathological studies indicate that TDP-43 is accumulated in brains of patients with PFN1 mutation. Here, we investigated the role of PFN1 mutations in the formation of pr...
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| Pubblicato in: | Prion |
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| Autori principali: | , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Taylor & Francis
2016
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5082967/ https://ncbi.nlm.nih.gov/pubmed/27432186 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/19336896.2016.1207033 |
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