Phosphorylation of TAR DNA-binding Protein of 43 kDa (TDP-43) by Truncated Casein Kinase 1δ Triggers Mislocalization and Accumulation of TDP-43

Intracellular aggregates of phosphorylated TDP-43 are a major component of ubiquitin-positive inclusions in the brains of patients with frontotemporal lobar degeneration and ALS and are considered a pathological hallmark. Here, to gain insight into the mechanism of intracellular TDP-43 accumulation,...

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Bibliographic Details
Published in:J Biol Chem
Main Authors: Nonaka, Takashi, Suzuki, Genjiro, Tanaka, Yoshinori, Kametani, Fuyuki, Hirai, Shinobu, Okado, Haruo, Miyashita, Tomoyuki, Saitoe, Minoru, Akiyama, Haruhiko, Masai, Hisao, Hasegawa, Masato
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2016
Subjects:
Molecular Bases of Disease
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4786690/
https://ncbi.nlm.nih.gov/pubmed/26769969
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.695379
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