Prion-like spreading of pathological α-synuclein in brain

α-Synuclein is the major component of filamentous inclusions that constitute the defining characteristic of neurodegenerative α-synucleinopathies. However, the molecular mechanisms underlying α-synuclein accumulation and spread are unclear. Here we show that intracerebral injections of sarkosyl-inso...

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Autors principals: Masuda-Suzukake, Masami, Nonaka, Takashi, Hosokawa, Masato, Oikawa, Takayuki, Arai, Tetsuaki, Akiyama, Haruhiko, Mann, David M. A., Hasegawa, Masato
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2013
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Original Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3613715/
https://ncbi.nlm.nih.gov/pubmed/23466394
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/brain/awt037
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