Methylene Blue Reduced Abnormal Tau Accumulation in P301L Tau Transgenic Mice

In neurodegenerative disorders, abnormally hyperphosphorylated and aggregated tau accumulates intracellularly, a mechanism which is thought to induce neuronal cell death. Methylene blue, a type of phenothiazine, has been reported to inhibit tau aggregation in vitro. However, the effect of methylene...

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Main Authors: Hosokawa, Masato, Arai, Tetsuaki, Masuda-Suzukake, Masami, Nonaka, Takashi, Yamashita, Makiko, Akiyama, Haruhiko, Hasegawa, Masato
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2012
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3527507/
https://ncbi.nlm.nih.gov/pubmed/23285020
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0052389
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