Beta Amyloid in Alzheimer’s Disease: Increased Deposition in Brain Is Reflected in Reduced Concentration in Cerebrospinal Fluid

BACKGROUND: A decreased concentration of beta amyloid (1–42) (Aβ42) has consistently been found in the cerebrospinal fluid (CSF) of patients with Alzheimer’s disease (AD) and is considered a diagnostic biomarker. However, it is not clear to which extent CSF Aβ42 levels are reflective of cerebral pat...

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Detalhes bibliográficos
Main Authors: Grimmer, Timo, Riemenschneider, Matthias, Förstl, Hans, Henriksen, Gjermund, Klunk, William E., Mathis, Chester A., Shiga, Tohru, Wester, Hans-Jürgen, Kurz, Alexander, Drzezga, Alexander
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2700302/
https://ncbi.nlm.nih.gov/pubmed/19268916
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.biopsych.2009.01.027
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