Reducing inflammation and rescuing FTD-related behavioral deficits in progranulin-deficient mice with α7 nicotinic acetylcholine receptor agonists

Mutations in the progranulin gene cause frontotemporal dementia (FTD), a debilitating neurodegenerative disease that involves atrophy of the frontal and temporal lobes and affects personality, behavior, and language. Progranulin-deficient mouse models of FTD exhibit deficits in compulsive and social...

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Publicado no:Biochem Pharmacol
Main Authors: Minami, S. Sakura, Shen, Vivian, Le, David, Krabbe, Grietje, Asgarov, Rustam, Perez-Celajes, Liberty, Lee, Chih-Hung, Li, Jinhe, Donnelly-Roberts, Diana, Gan, Li
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4859338/
https://ncbi.nlm.nih.gov/pubmed/26206194
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bcp.2015.07.016
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