Microglial NFκB-TNFα hyperactivation induces obsessive–compulsive behavior in mouse models of progranulin-deficient frontotemporal dementia

Frontotemporal dementia (FTD) is the second most common dementia before 65 years of age. Haploinsufficiency in the progranulin (GRN) gene accounts for 10% of all cases of familial FTD. GRN mutation carriers have an increased risk of autoimmune disorders, accompanied by elevated levels of tissue necr...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Krabbe, Grietje, Minami, S. Sakura, Etchegaray, Jon I., Taneja, Praveen, Djukic, Biljana, Davalos, Dimitrios, Le, David, Lo, Iris, Zhan, Lihong, Reichert, Meredith C., Sayed, Faten, Merlini, Mario, Ward, Michael E., Perry, David C., Lee, Suzee E., Sias, Ana, Parkhurst, Christopher N., Gan, Wen-biao, Akassoglou, Katerina, Miller, Bruce L., Farese, Robert V., Gan, Li
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2017
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5441749/
https://ncbi.nlm.nih.gov/pubmed/28438992
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1700477114
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