Acetylated tau destabilizes the cytoskeleton in the axon initial segment and is mislocalized to the somatodendritic compartment

BACKGROUND: Neurons are highly polarized cells in which asymmetric axonal-dendritic distribution of proteins is crucial for neuronal function. Loss of polarized distribution of the axonal protein tau is an early sign of Alzheimer’s disease (AD) and other neurodegenerative disorders. The cytoskeletal...

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Detalhes bibliográficos
Publicado no:Mol Neurodegener
Main Authors: Sohn, Peter Dongmin, Tracy, Tara E., Son, Hye-In, Zhou, Yungui, Leite, Renata E. P., Miller, Bruce L., Seeley, William W., Grinberg, Lea T., Gan, Li
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2016
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4928318/
https://ncbi.nlm.nih.gov/pubmed/27356871
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13024-016-0109-0
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