Acetylated tau destabilizes the cytoskeleton in the axon initial segment and is mislocalized to the somatodendritic compartment

BACKGROUND: Neurons are highly polarized cells in which asymmetric axonal-dendritic distribution of proteins is crucial for neuronal function. Loss of polarized distribution of the axonal protein tau is an early sign of Alzheimer’s disease (AD) and other neurodegenerative disorders. The cytoskeletal...

Полное описание

Сохранить в:
Библиографические подробности
Опубликовано в: :Mol Neurodegener
Главные авторы: Sohn, Peter Dongmin, Tracy, Tara E., Son, Hye-In, Zhou, Yungui, Leite, Renata E. P., Miller, Bruce L., Seeley, William W., Grinberg, Lea T., Gan, Li
Формат: Artigo
Язык:Inglês
Опубликовано: BioMed Central 2016
Предметы:
Research Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4928318/
https://ncbi.nlm.nih.gov/pubmed/27356871
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13024-016-0109-0
Метки: Добавить метку
Нет меток, Требуется 1-ая метка записи!

Схожие документы