Extracellular Tau Oligomers Induce Invasion of Endogenous Tau into the Somatodendritic Compartment and Axonal Transport Dysfunction

Aggregates composed of the microtubule associated protein, tau, are a hallmark of Alzheimer’s disease and non-Alzheimer’s tauopathies. Extracellular tau can induce the accumulation and aggregation of intracellular tau, and tau pathology can be transmitted along neural networks over time. There are s...

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Vydáno v:J Alzheimers Dis
Hlavní autoři: Swanson, Eric, Breckenridge, Leigham, McMahon, Lloyd, Som, Sreemoyee, McConnell, Ian, Bloom, George S.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2017
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5581403/
https://ncbi.nlm.nih.gov/pubmed/28482642
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3233/JAD-170168
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