Alzheimer brain-derived tau oligomers propagate pathology from endogenous tau

Intracerebral injection of brain extracts containing amyloid or tau aggregates in transgenic animals can induce cerebral amyloidosis and tau pathology. We extracted pure populations of tau oligomers directly from the cerebral cortex of Alzheimer disease (AD) brain. These oligomers are potent inhibit...

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Main Authors: Lasagna-Reeves, Cristian A., Castillo-Carranza, Diana L., Sengupta, Urmi, Guerrero-Munoz, Marcos J., Kiritoshi, Takaki, Neugebauer, Volker, Jackson, George R., Kayed, Rakez
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2012
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3463004/
https://ncbi.nlm.nih.gov/pubmed/23050084
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep00700
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