Alzheimer brain-derived tau oligomers propagate pathology from endogenous tau

Intracerebral injection of brain extracts containing amyloid or tau aggregates in transgenic animals can induce cerebral amyloidosis and tau pathology. We extracted pure populations of tau oligomers directly from the cerebral cortex of Alzheimer disease (AD) brain. These oligomers are potent inhibit...

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Autores principales: Lasagna-Reeves, Cristian A., Castillo-Carranza, Diana L., Sengupta, Urmi, Guerrero-Munoz, Marcos J., Kiritoshi, Takaki, Neugebauer, Volker, Jackson, George R., Kayed, Rakez
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group 2012
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3463004/
https://ncbi.nlm.nih.gov/pubmed/23050084
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep00700
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