O6-benzylguanine enhances the sensitivity of a glioma xenograft with low O6-alkylguanine-DNA alkyltransferase activity to temozolomide and BCNU.

Por Wedge, S. R., Newlands, E. S.
Publicado em 1996

ZD6474 – a novel inhibitor of VEGFR and EGFR tyrosine kinase activity

Por Ryan, A J, Wedge, S R
Publicado em 2005

Comparison of the liver subcellular distribution of free daunomycin and that bound to galactosamine targeted N-(2-hydroxypropyl)methacrylamide copolymers, following intravenous adm...

Por Wedge, S. R., Duncan, R., Kopeckova, P.
Publicado em 1991

3-aminobenzamide and/or O6-benzylguanine evaluated as an adjuvant to temozolomide or BCNU treatment in cell lines of variable mismatch repair status and O6-alkylguanine-DNA alkyltr...

Por Wedge, S. R., Porteous, J. K., Newlands, E. S.
Publicado em 1996

Ex vivo treatment of patient biopsies as a novel method to assess colorectal tumour response to the MEK1/2 inhibitor, Selumetinib

Por Novo, Sonia M., Wedge, Stephen R., Stark, Lesley A.
Publicado no Sci Rep (2017)

Potentiation of temozolomide and BCNU cytotoxicity by O(6)-benzylguanine: a comparative study in vitro.

Por Wedge, S. R., Porteus, J. K., May, B. L., Newlands, E. S.
Publicado em 1996

DNAPK Inhibition Preferentially Compromises the Repair of Radiation-induced DNA Double-strand Breaks in Chronically Hypoxic Tumor Cells in Xenograft Models

Por Jiang, Yanyan, Willmore, Elaine, Wedge, Stephen R., Ryan, Anderson J.
Publicado no Mol Cancer Ther (2021)

ZD1839 (‘Iressa’), a specific oral epidermal growth factor receptor-tyrosine kinase inhibitor, potentiates radiotherapy in a human colorectal cancer xenograft model

Por Williams, K J, Telfer, B A, Stratford, I J, Wedge, S R
Publicado em 2002

Use of dynamic contrast-enhanced MRI to evaluate acute treatment with ZD6474, a VEGF signalling inhibitor, in PC-3 prostate tumours

Por Checkley, D, Tessier, J J, Kendrew, J, Waterton, J C, Wedge, S R
Publicado em 2003

Aurora A regulates expression of AR-V7 in models of castrate resistant prostate cancer

Por Jones, Dominic, Noble, Martin, Wedge, Steve R., Robson, Craig N., Gaughan, Luke
Publicado no Sci Rep (2017)

N-(2-hydroxypropyl)methacrylamide copolymers targeted to the hepatocyte galactose-receptor: pharmacokinetics in DBA2 mice.

Por Seymour, L. W., Ulbrich, K., Wedge, S. R., Hume, I. C., Strohalm, J., Duncan, R.
Publicado em 1991

Development of a fluorescence-based cellular apoptosis reporter

Por Balderstone, Lucy A, Dawson, John C, Welman, Arkadiusz, Serrels, Alan, Wedge, Stephen R, Brunton, Valerie G
Publicado no Methods Appl Fluoresc (2019)

Tumor cells with KRAS or BRAF mutations or ERK5/MAPK7 amplification are not addicted to ERK5 activity for cell proliferation

Por Lochhead, Pamela A., Clark, Jonathan, Wang, Lan-Zhen, Gilmour, Lesley, Squires, Matthew, Gilley, Rebecca, Foxton, Caroline, Newell, David R., Wedge, Stephen R., Cook, Simon J.
Publicado no Cell Cycle (2016)

Inhibition of poly(ADP-ribose) polymerase-1 by olaparib (AZD2281) increases the radiosensitivity of a lung tumor xenograft

Por Senra, Joana M., Telfer, Brian A., Cherry, Kim E., McCrudden, Cian M., Hirst, David G., O’Connor, Mark J., Wedge, Stephen R., Stratford, Ian J.
Publicado em 2011

Development and exploitation of a novel mutant androgen receptor modelling strategy to identify new targets for advanced prostate cancer therapy

Por O'Neill, Daniel, Jones, Dominic, Wade, Mark, Grey, James, Nakjang, Sirintra, Guo, Wenrui, Cork, David, Davies, Barry R., Wedge, Steve R., Robson, Craig N., Gaughan, Luke
Publicado no Oncotarget (2015)

Differential Regulation of G1 CDK Complexes by the Hsp90-Cdc37 Chaperone System

Por Hallett, Stephen T., Pastok, Martyna W., Morgan, R. Marc L., Wittner, Anita, Blundell, Katie L.I.M., Felletar, Ildiko, Wedge, Stephen R., Prodromou, Chrisostomos, Noble, Martin E.M., Pearl, Laurence H., Endicott, Jane A.
Publicado no Cell Rep (2017)

O6-methylguanine-DNA methyltransferase in pretreatment tumour biopsies as a predictor of response to temozolomide in melanoma.

Por Middleton, M. R., Lunn, J. M., Morris, C., Rustin, G., Wedge, S. R., Brampton, M. H., Lind, M. J., Lee, S. M., Newell, D. R., Bleehen, N. M., Newlands, E. S., Calvert, A. H., Margison, G. P., Thatcher, N.
Publicado em 1998

Identification of a novel ligand for the ATAD2 bromodomain with selectivity over BRD4 through a fragment growing approach

Por Miller, Duncan C., Martin, Mathew P., Adhikari, Santosh, Brennan, Alfie, Endicott, Jane A., Golding, Bernard T., Hardcastle, Ian R., Heptinstall, Amy, Hobson, Stephen, Jennings, Claire, Molyneux, Lauren, Ng, Yvonne, Wedge, Stephen R., Noble, Martin E. M., Cano, Celine
Publicado no Org Biomol Chem (2018)

Inhibition of monocarboxyate transporter 1 by AZD3965 as a novel therapeutic approach for diffuse large B-cell lymphoma and Burkitt lymphoma

Por Noble, Richard A., Bell, Natalie, Blair, Helen, Sikka, Arti, Thomas, Huw, Phillips, Nicole, Nakjang, Sirintra, Miwa, Satomi, Crossland, Rachel, Rand, Vikki, Televantou, Despina, Long, Anna, Keun, Hector C., Bacon, Chris M., Bomken, Simon, Critchlow, Susan E., Wedge, Stephen R.
Publicado no Haematologica (2017)

Guidelines for the welfare and use of animals in cancer research

Por Workman, P, Aboagye, E O, Balkwill, F, Balmain, A, Bruder, G, Chaplin, D J, Double, J A, Everitt, J, Farningham, D A H, Glennie, M J, Kelland, L R, Robinson, V, Stratford, I J, Tozer, G M, Watson, S, Wedge, S R, Eccles, S A
Publicado em 2010