Identification of a novel ligand for the ATAD2 bromodomain with selectivity over BRD4 through a fragment growing approach

ATAD2 is an ATPase that is overexpressed in a variety of cancers and associated with a poor patient prognosis. This protein has been suggested to function as a cofactor for a range of transcription factors, including the proto-oncogene MYC and the androgen receptor. ATAD2 comprises an ATPase domain,...

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Detaylı Bibliyografya
Yayımlandı:Org Biomol Chem
Asıl Yazarlar: Miller, Duncan C., Martin, Mathew P., Adhikari, Santosh, Brennan, Alfie, Endicott, Jane A., Golding, Bernard T., Hardcastle, Ian R., Heptinstall, Amy, Hobson, Stephen, Jennings, Claire, Molyneux, Lauren, Ng, Yvonne, Wedge, Stephen R., Noble, Martin E. M., Cano, Celine
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Royal Society of Chemistry 2018
Konular:
Chemistry
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6102691/
https://ncbi.nlm.nih.gov/pubmed/29469144
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c8ob00099a
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