O6-methylguanine-DNA methyltransferase in pretreatment tumour biopsies as a predictor of response to temozolomide in melanoma.

Resistance of tumour cells to methylating and monochloroethylating agents in vitro and in vivo has been linked to levels of the DNA repair protein O6-methylguanine-DNA methyltransferase (MGMT). In a clinical trial of temozolomide in advanced malignant melanoma, the relationship between pretreatment...

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Hauptverfasser: Middleton, M. R., Lunn, J. M., Morris, C., Rustin, G., Wedge, S. R., Brampton, M. H., Lind, M. J., Lee, S. M., Newell, D. R., Bleehen, N. M., Newlands, E. S., Calvert, A. H., Margison, G. P., Thatcher, N.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group|1 1998
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2062985/
https://ncbi.nlm.nih.gov/pubmed/9820180
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