Effect of alternative temozolomide schedules on glioblastoma O(6)-methylguanine-DNA methyltransferase activity and survival

BACKGROUND: O(6)-methylguanine-DNA methyltransferase (MGMT) expression in glioblastoma correlates with temozolomide resistance. Dose-intense temozolomide schedules deplete MGMT activity in peripheral blood mononuclear cells; however, no published data exist evaluating the effect of temozolomide sche...

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Detalhes bibliográficos
Main Authors: Robinson, C G, Palomo, J M, Rahmathulla, G, McGraw, M, Donze, J, Liu, L, Vogelbaum, M A
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2010
Assuntos:
Translational Therapeutics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2939788/
https://ncbi.nlm.nih.gov/pubmed/20628383
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6605792
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