O(6)-Methylguanine DNA methyltransferase protein expression in tumor cells predicts outcome of temozolomide therapy in glioblastoma patients

O(6)-Methylguanine DNA methyltransferase (MGMT) is implicated as a major predictive factor for treatment response to alkylating agents including temozolomide (TMZ) of glioblastoma multiforme (GBM) patients. However, whether the MGMT status in GBM patients should be detected at the level of promoter...

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Bibliografiske detaljer
Main Authors: Spiegl-Kreinecker, Sabine, Pirker, Christine, Filipits, Martin, Lötsch, Daniela, Buchroithner, Johanna, Pichler, Josef, Silye, Rene, Weis, Serge, Micksche, Michael, Fischer, Johannes, Berger, Walter
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2010
Fag:
Basic and Translational Investigations
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2940563/
https://ncbi.nlm.nih.gov/pubmed/20150365
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nop003
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