O(6)-Methylguanine DNA methyltransferase protein expression in tumor cells predicts outcome of temozolomide therapy in glioblastoma patients

O(6)-Methylguanine DNA methyltransferase (MGMT) is implicated as a major predictive factor for treatment response to alkylating agents including temozolomide (TMZ) of glioblastoma multiforme (GBM) patients. However, whether the MGMT status in GBM patients should be detected at the level of promoter...

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Bibliografische gegevens
Hoofdauteurs: Spiegl-Kreinecker, Sabine, Pirker, Christine, Filipits, Martin, Lötsch, Daniela, Buchroithner, Johanna, Pichler, Josef, Silye, Rene, Weis, Serge, Micksche, Michael, Fischer, Johannes, Berger, Walter
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Oxford University Press 2010
Onderwerpen:
Basic and Translational Investigations
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2940563/
https://ncbi.nlm.nih.gov/pubmed/20150365
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nop003
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