O(6)-Methylguanine DNA methyltransferase protein expression in tumor cells predicts outcome of temozolomide therapy in glioblastoma patients

O(6)-Methylguanine DNA methyltransferase (MGMT) is implicated as a major predictive factor for treatment response to alkylating agents including temozolomide (TMZ) of glioblastoma multiforme (GBM) patients. However, whether the MGMT status in GBM patients should be detected at the level of promoter...

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Detalhes bibliográficos
Main Authors: Spiegl-Kreinecker, Sabine, Pirker, Christine, Filipits, Martin, Lötsch, Daniela, Buchroithner, Johanna, Pichler, Josef, Silye, Rene, Weis, Serge, Micksche, Michael, Fischer, Johannes, Berger, Walter
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2010
Assuntos:
Basic and Translational Investigations
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2940563/
https://ncbi.nlm.nih.gov/pubmed/20150365
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nop003
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