O(6)-Methylguanine DNA methyltransferase protein expression in tumor cells predicts outcome of temozolomide therapy in glioblastoma patients

O(6)-Methylguanine DNA methyltransferase (MGMT) is implicated as a major predictive factor for treatment response to alkylating agents including temozolomide (TMZ) of glioblastoma multiforme (GBM) patients. However, whether the MGMT status in GBM patients should be detected at the level of promoter...

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Bibliographische Detailangaben
Hauptverfasser: Spiegl-Kreinecker, Sabine, Pirker, Christine, Filipits, Martin, Lötsch, Daniela, Buchroithner, Johanna, Pichler, Josef, Silye, Rene, Weis, Serge, Micksche, Michael, Fischer, Johannes, Berger, Walter
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2010
Schlagworte:
Basic and Translational Investigations
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2940563/
https://ncbi.nlm.nih.gov/pubmed/20150365
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nop003
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